[7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. [14] In other words, you can 'normalize' the main clinically measurable parameter associated with 'low thyroid function,' i.e. Article published in Wakeup-World.Com. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: Recently T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. Allthewebsites Directory - A niche web directory offering website promotion and other webmaster resources. Endocrinol. A study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related diseases.. [2], The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. The estimated 2.3 million new cases indicate that 1 in every 8 cancers diagnosed in . undefined will no longer be visible to you including posts, replies, and photos. It's usually based on the results of blood tests. Symptoms can include fatigue, shortness of breath with exercise, and decreased ability to exercise. Hypothyroidism can cause depression and, without treatment, the symptoms intensify and directly affect the mental state. Is Drug-Based Medicine a Form of Human Sacrifice? Non-ASPS articles which could be relevant. [13] Hollowell JG, Staehling NW, Flanders WD, et al. Oops I have just bought my first jar of marmalade in over ten years! Perhaps she and I could co-author? [8] van Doorn J, Roelfsema F, van der Heide D: Concentration of thyroxine and 3,5,3'-triiodotyronine in several rat tissue in vivo: the effect of hypothyroidism. [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. radioactive treatments. A distorted idea of human nature is sold when people are treated as "the market. In the U.S., the overall five-year survival rate for patients diagnosed with lung cancer is 25%, which is a 21% improvement over the . Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. ', Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer. The Goji Berry: The Jolly Super Food That Gives Yo How to Prevent and Treat Insect Bites Without Hars Supreme Court Rules Drug Companies Exempt From Law Spain Study Confirms Hemp Oil Cures Cancer without Wheatgrass Turns Gray Hair Back to Its Natural Color, Medicinal Cannabis Used To Prevent Cancer Growth. They only reappear when I need to fine tune the medication. She wrote about a product called Thyrtophin PMG. I cried with joy when I found out there was something really wrong with me. I had doctor after doctor tell me it was in my head or I was menopausal. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer millions treated for hypothyroidism at risk for lung cancer The omnipresent environmental contaminant perchlorate, an ingredient in jet fuel, is also a primary cause of hypothyroidism, but is almost never tested for by the conventional endocrinologists in their patient evaluations. Even in the mildest form, hypothyroidism affects the heart. Military veterans face increased risk of HPV-related cancer due to low A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). Patient characteristics. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as "hypothyroidism"? Methods: The study group included 35 patients (15 women, 20 men, 65.8 7.1 years) with NSCLC in stage IIIB (n = 16, 45.7%) and IV (n = 19,54.3%) who were treated with nivolumab. Endocrinology 1985, 117:12011208. In my opinion, the science of the study doesn't support the conclusion. Physician/Author on Facebook. (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). The reality is that most cases of hypothyroidism today are diagnosed in populations who are experiencing a combination of basic nutritional deficiencies and chemical exposures, or who are simply going through a temporary down-cycle in thyroid function following a natural change, such as the natural postpartum drop that occurs in women after giving birth. It does not seem to quantify the increased risk, and it keeps saying it is hyperthyroidism that causes the oxidised stress. In fact, it is the high levels of T4 that make them more susceptible to cancer. Study: Millions Treated for Hypothyroidism At Risk of Lung Cancer. Untreated hypothyroidism increases morbidity and mortality. Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM. This article is copyrighted by GreenMedInfo LLC, 2013, Some features are currently member only features. This is a news report of the research, so I can't learn the details of how the science was conducted. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low . The Dangers of Tylenol: Is it Time to for the FDA Chile: Psychiatrist Leads Crusade To Legalize Mari 13 Things Sure To Slow Down Your Metabolism. This relatively symptom-free reservoir of hypothyroid cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. I am going to go for a walk with my dog :)). hyperthyroidism. rocket fuel, pesticides, fluoride, which induce low thyroid function. I have posted the link now. J Endocrinol Invest. Acta Endocrinol 1988, 118:460464. Diagnosed 1/12 with lung cancer out of the blue. Risk of cancer in long-term levothyroxine users: Retrospective - PubMed The authors expanded on their findings further: "However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. I am convinced that my lung cancer is related to the thyroid/auto immune issues I've had for years. The first blood test typically done to diagnose hypothyroidism measures the level of thyroid-stimulating hormone (TSH) in the blood. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them. [1] Hercbergs AH, Ashur-Fabian O, Garfield D: Thyroid hormone and cancer: clinical studies of hypothyroidism in oncology. With the 2013 announcement by a National Cancer Institutecommissioned expert panel that a variety of so-called indolent neoplasms such as ductal carcinoma in situ(DCIS) and high-grade prostatic intraepithelial neoplasia (HGPIN), formerly understood to be forms of breast and prostate cancers, respectively, should be renamed to reflect their intrinsic benignity, a veritable sea change is occurring within the conventional medical establishment. Biomedicine today is awash in controversy associated with the overdiagnosis and overtreatment of asymptomatic populations. Acta Endocrinol 1988, 118:460464. and our Medical Authoritys System Kills: FDA-Approved Dru Cognitive Impairment, Memory Loss and Alzheimer's Soy Lecithin: How It Negatively Affects Your Healt Cannabis Oil Cures Cancer -Lincoln Horsley's Story New Information Dissolves Illusions About Vaccines Grounding Helps Thin Dangerously Thick Blood and F Tart Cherries Relieve Osteoarthritis Pain, Lieberman's Massive Connections To Big Pharma, Utopian 'Harvest Your Own' Groceries Coming Up. Is that what releases free radicals? The aim of the study was to assess the occurrence and nature of immune-related endocrine adverse events (irAEs) among patients with non-small-cell lung cancer (NSCLC) treated with nivolumab. Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. Angiology 2000, 51:S65S68. [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. Tokushima J Exp Med 1991, 38:2535. Metab.87 (2): 48999. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: [I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. I wonder if only t3 treatments are preferable than t4 and t3 ? But that's just me. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. Hypothyroidism results from low levels of thyroid hormone with varied etiology and manifestations. Epub 2013 Mar 28. That's all. Sin un requerimiento, el cumplimiento voluntario por parte de tu Proveedor de servicios de Internet, o los registros adicionales de un tercero, la informacin almacenada o recuperada slo para este propsito no se puede utilizar para identificarte. They found no significant correlation between T4 sales and breast, colorectal and gastriccancers, but did find a significant correlation for lung cancer (p < 0.05) corrected forsmoking and age. Eventually, the decline in thyroid hormone production can result in any of the following: Fatigue and sluggishness. Millions Treated For Hypothyroidism At Risk For Lung Cancer Join the forum, it's quick and easy . elevated TSH, without actually improving the overall physiological situation, nor the patients subjective experience of well being. In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. Ultimately, this latest Italian study is bringing to our attention one of what is likely a wide range of unintended, adverse health effects associated with the overdiagnosis and subsequent overtreatment of hypothyroidism, and the underlying failure of the conventional, largely drug-based paradigm to comprehend the causes and real solutions of disease and human suffering. I don't believe there are thousands of people on to high a dose of t4, so why does it feel they are hyper? weight loss, anorexia). " View the data on GreenMedInfos Hypothyroidism Research page. When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious. Currently, the best practical approach is to base treatment decisions on the degree of TSH elevation, thyroid autoimmunity, and associated comorbidities. Patients with undertreated hypothyroidism at higher risk for longer In fact, a 2004 study in subjects with normal thyroid function found that administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo, while the combined synthetic T4-T3 supplement leads to a worsening of mood in summer and no improvement in winter, indicating supporting glandular function is superior to replacement therapy, as well as the role seasonality may play in hormone function and hormone treatment interventions. [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. They also noted that oxidative stress is one of the causes of chronic diseases and cancer. Asesora y Consultora Web3 para empresas. CRF encompasses physical, emotional, and/or cognitive tiredness; is related to cancer or cancer treatments; and interferes with multiple dimensions of health-related quality of life (1-3).CRF is poorly understood, underrecognized, and undertreated. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). Objectives: To examine site-specific cancer incidence and mortality and to evaluate the radiation dose-response association after RAI treatment for hyperthyroidism. Thyroid disease is a major public health concern worldwide. It is very tormenting (for me anyhow) to not know why I got this disease. Monaldi Arch Chest Dis 2003, 59:140145. Lung cancer survivors support group and discussion community, http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-lung-cancers?utm_source=www.GreenMedInfo.com&utm_campaign=2189ddd3c1-Greenmedinfo&utm_medium=email&utm_term=0_193c8492fb-2189ddd3c1-87046221. Levothyroxine and cancer risk study : Hi sorry to - Thyroid UK Increased sensitivity to cold. [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. Heart problems. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. Hashimoto's disease progresses slowly over the years. For a better experience, please enable JavaScript in your browser before proceeding. Cancer Risk After Radioactive Iodine Treatment for - PubMed I have posted the link, so you can see if it has any merit. [4], DI activity in lung cancer was found to be lower than in peripheral lung tissue.[5]. There are many links attached. Nanosized aluminum being sprayed in the atmosphere CDC Admits as Many as 30 Million Americans Could b Why Turmeric May Be the Diseased Liver's Best Friend. If I can help someone, fine. [6] Venditti P, Di Stefano L, Di Meo S: Oxidative stress in cold induced hyperthyroid state. Kelly Mellott LinkedIn: Nodify Lung: Nodule Risk Assessment | Biodesix The Flu Propaganda Matrix Continues To Promote Fea B Vitamins Slow Alzheimer's and Grey Matter Loss. by D.ap Tue Feb 21, 2017 10:40 am, Powered by phpBB Forum Software phpBB Limited. The authors of the study pointed out that levothyroxine (T4) treatment can lead to medication-induced (iatrogenic) thyroid over-activity (hyperthyroidism) and oxidative stress that can lead to a significant patient discomfort. [12] Cesarone MR, Belcaro G, Nicolaides AN, Incandela L, De Sanctis MT, Barsotti A: San Valentino epidemiologic project. Yet Another Frankenfood Pandoras Box: the Majorit How Medical Science Proves that Black Is White. Based just on this article, I think the study's conclusion that Synthroid may cause an increase in lung cancer risk is premature. Treating Elderly for Subclinical Hypothyroidism Can Boost Mortality Rates As a never smoker I truly wish I smoked so I could just say that's why I got this. Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. This is a horrible disease that ravages the body. Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. arizona lockdown status today; tiktok unblocked from school; samantha and savannah concepcion 2004 Jun;9(2):157-79. ", Cure Alveolar Soft Part Sarcoma International, COMPLETED - Dana Farber Vaccine Clinical Trial (GVAX), Axitinib and Pembrolizumab (Keytruda) in Miami, US, TECENTRIQ (atezolizumab) by Genentech, Treatment of Non-Resectable Primary Tumor, Immune checkpoint inhibitors ICI (PD-1 and PD-L1 targeting drugs), Toxicity, problems and potentiation strategies, Treatment response criteria and evaluation/scanning problems/rare cases, treatment discontinuation/re-treatment, Side effects/complications of the local ablations, High intensity focused ultrasound (HIFU), Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer, http://www.greenmedinfo.com/blog/study- ng-cancers. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. J Exp Biol 2010, 213:28992911. Sub-laboratory hypothyroidism and the empirical use of Armour thyroid.Altern Med Rev. Compared to patients without hypothyroidism, those with a high TSH level before hospitalization stayed in the hospital 1.2 days longer and had a 49% higher risk of 30-day readmission and a 43% . I have been reading Izabella Wentz. I posted it to see what anyone had to add. Study: Millions Treated for Hypothyroidism At Risk of Lung Cancer. Respiratory system Hypothyroidism weakens the respiratory muscles and decreases lung function. At GreenMedInfo.com, we have indexed plenty of peer-reviewed research on over 30 natural substances, including nutrients and minerals, which may help to resolve low thyroid function, and conversely, over 30 unnatural substances, e.g. It's possible, for instance, that the reason both sales of Synthroid and the incidence of lung cancer increased is due to an environmental condition that affected both the thyroid and the lungs. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. The very concept of "marketing" is at odds with the real nature of these materials, which has to do with the protection and expansion of our nature and potential. Study: Millions Treated for Hypothyroidism at Risk of Lung Cancer Subclinical hypothyroidism: When to treat | Cleveland Clinic Journal of 2 Hypothyroidism is the most common type of thyroid disorder, and women's risk of hypothyroidism is five to eight times higher than that of . Clin Cancer Res 2011, 30:77. For more, visitGreenMedInfo.comand Facebook.com/GreenMedInfo, or sign up forGreenMedInfos free e-Newsletter. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. If it's high, the test is done again, along with a blood test for the thyroid hormone T-4. Tokushima J Exp Med 1991, 38:2535. Nope. In 2020 alone, there were more than 2.2 million new cases and 1.8 million deaths from lung cancer globally. [10] Hofer T, Desbaillets I, Hpfl G, Wenger RH, Gassmann M: Characterization of HIFD-1 alpha overexpressing Hela cells and implication for gene therapy. I don't think so. The article also stresses that too many people are being given the diagnosis of either hypo or hyperthyroidism. I'm just saying the evidence presented in this article isn't very strong, and more study is needed to show Synthroid causes lung cancer. One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore back up causing excessive T4 activity, i.e. Just for entertainment value take a look at some more dodgy correlations : I rather liked the correlation between consumption of orange marmalade and birth rate - in the years after the second world war if I remember correctly. May be of interest: Study: Millions Treated for Hypothyroidism At Risk for, Non-small cell lung cancer - Adenocarcinoma, Non-small cell lung cancer - Squamous cell, Top 5 Questions to Ask Your Lung Cancer Doctor, Patient & Caregiver Network Member Resources, Not A Member Yet? Sayer Ji is the founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, and SteeringCommittee Memberof the Global Non-GMO Foundation. Find how some diseases can be healed with alternative medicine, and share your experience with A study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' 500+ pages of Natural Medicine Alternatives and Information. Hashimoto's disease - Symptoms and causes - Mayo Clinic Endocrinology 2008, 149:22412250. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious. As a person with Graves Disease, I underwent 6 cycles of radio-ablation using i 131 to 'fry' my thyroid gland as surgery was deemed too risky due to the vascularity and size of my gland. Thank you for bringing it to our attention. Increased sleepiness. [4] Ratcliffe JG, Stack BH, Burt RW, Radcliffe WA, Spilg WG, Cuthbert J, Kennedy RS: Thyroid function in lung cancer. LifeGivingStore.comRed Light Therapy - Hydrogen Water Generators - Cascara Sagrada - Vitamins, Minerals & Amino Acid Supplements - Cocoa Products - Handcrafted Soaps - Grass Fed Organs & Glandulars - Nano Soma. Obesity epidemic caused by EMF exposures in the ho War on Health - The FDA's Cult of Tyranny. Do endocrine adverse events predict longer progression-free survival [1] Hercbergs AH, Ashur-Fabian O, Garfield D: Thyroid hormone and cancer: clinical studies of hypothyroidism in oncology. In comparison, 62.4% of female and 37% of male . However, they pointed out that the opposite was actually described, and that hypothyroidism reduces the aggressiveness of some cancers because of the presence of thyroid hormone receptors on cancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness of cancers.[1]. Post by D.ap Tue Feb 21, 2017 6:40 pm "A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and . As I am the caregiver for my dad who has Stage IV lung Cancer, I hope more research can be done on this topic soon. In addition, untreated hypothyroidism is associated with a gradual decline in cognitive function and memory. Thanks, I am not suggesting I believe in all that I see. It took over five years before the someone figured out my ongoing symptoms were due to hypothyroidism. Targeted therapy for lung cancer: Side effects and more Compression of the trachea, which may be positional, can occur with nodular goiters and thyroid cancer, and the latter can metastasize to the lungs. [4], More recently DI activity in lung cancer was found to be lower than in peripheral lung tissue.[5]. Risk of cancer in longterm levothyroxine users: Retrospective Importance: Whether radioactive iodine (RAI) therapy for hyperthyroidism can increase cancer risk remains a controversial issue in medicine and public health. Not what people like me are saying. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. It does not necessarily imply one thing caused the other. With the recent announcement by a National Cancer Institute commissioned expert panel that a variety of so-called 'indolent' neoplasms such as ductal carcinoma in situ (DCIS) and high-grade prostatic intraepithelial neoplasia (HGPIN), formerly understood to be forms of breast and prostate cancers, respectively, should be renamed to reflect their intrinsic benignity, a veritable sea change is occurring within the conventional medical establishment. Factors found to be associated with mortality were age, senile dementia, congestive heart failure, chronic renal failure, and a history of cerebrovascular disease. Or, simply look at what the young-adult,T-score based definition of osteoporosis and osteopeniahas done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer I honestly do not know. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as hypothyroidism? In my view the paper isn't worth the pixels used to display it on a screen.
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